Journal: Frontiers in Pharmacology
Article Title: Optimizing the enzymatic release of MMAE from iso DGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker
doi: 10.3389/fphar.2023.1215694
Figure Lengend Snippet: Cell viability curves and calculated IC 50 values obtained after 30 min treatment of cancer cell lines with different integrin α V β 3 receptor level of expression with the conjugate 2 , free drug MMAE, and free ligand, followed by washout and further incubation of the cells up to 72 h (A) U87MG. (B) SK-MEL-28. (C) SK-OV-3. (D) A549.
Article Snippet: U87MG human malignant glioma, SK-MEL-28 human melanoma, SK-OV-3 human ovarian cancer, and A549 human lung cancer cell lines were purchased from ATCC.
Techniques: Expressing, Incubation